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Human Trials

April 24, 2018 Aging and Disease: 2.3 – Cell senescence, Changes in Gene Expression
Aging diseases,  Alzheimer's disease,  Epigenetics,  Osteoarthritis,  Osteoporosis,  senescent cells,  Telomerase,  Telomeres

Changes in gene expression underlie aging and age-related diseases. There is all-but-universal (and equally unwarranted) assumption that both aging and age-related diseases are genetic. We see articles on “aging genes” and “genes that cause Alzheimer’s disease” (or genes that cause heart disease, osteoarthritis, etc.). The reality is that both aging and age-related diseases are not […]

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January 23, 2018 Aging and Disease: 0.1 – A Prologue
Aging diseases,  Alzheimer's disease,  Biotech,  Epigenetics,  microglia,  mitochondria,  Osteoarthritis,  senescent cells,  Telomerase,  Telomeres,  The Telomerase Revolution

Aging and Disease 0.1 – A Prologue Over the past 20 years, I have published numerous articles, chapters, and books explaining how aging and age-related disease work, as well as the potential for intervention in both aging and age-related disease. The first of these publications was Reversing Human Aging (1996), followed by my articles in […]

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December 31, 2017 Human Nature
Aging diseases,  Alzheimer's disease,  Big Pharma,  Biotech,  Telocyte,  Telomerase,  Telomeres

Many of you have written to me, expressing surprise about the lack of public reaction (such as media interest) regarding the potential for telomerase therapy to treat age-related diseases. Some of you wonder why people (and particularly the media) “don’t get it”. I’ve had the same thought for a bit more than two decades now, […]

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December 1, 2017 Big Pharma: Still Looking for the Horse
Aging diseases,  Alzheimer's disease,  Big Pharma,  Biotech,  Epigenetics,  microglia,  mitochondria,  senescent cells,  solanezumab,  Telocyte,  Telomerase,  Telomeres

About a century ago, in a small American town, the first automobile chugged to a stop in front of the general store, where a local man stared at the apparition in disbelief, then asked “where’s your horse?” A long explanation followed, involving internal combustion, pistons, gasoline, and driveshafts. The local listened politely but with growing […]

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October 10, 2017 Should everyone respond the same to telomerase?
Aging diseases,  Alzheimer's disease,  Biotech,  Epigenetics,  microglia,  senescent cells,  Telocyte,  Telomerase,  Telomeres

A physician friend asked if a patient’s APOE status (which alleles they carry, for example APOE4, APOE3, or APOE2) would effect how well they should respond to telomerase therapy. Ideally, it may not make much difference, except that the genes you carry (including the APOE genes and the alleles for each type of APOE gene, […]

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September 20, 2017 Genes and Aging
Aging diseases,  Alzheimer's disease,  Epigenetics,  progeria,  senescent cells,  Telomerase,  Telomeres

Several of you have asked why I don’t update this blog more often. My priority is to take effective interventions for age-related diseases to FDA phase 1 human trials, rather than blogging about the process. Each week, Outlook reminds me to update the blog, but there are many tasks that need doing if we are […]

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