mitochondria

I confess that I’ve yet to find time to continue through each of several age-related diseases. In partial recompense, let me offer the following, which is adapted from the quarterly newsletter that I put out for Telocyte. While it focuses on Alzheimer’s disease, the import is generic, applying to all age-related diseases. How Alzheimer’s works […]

Aging causes disease. To many people, the relationship is even closer: aging is a disease. The latter view is controversial. Most biologists and physicians would view aging as a “natural process” and contend that “normal aging” is independent of disease. Aging, in this view is not a disease, although it certainly causes disease. They often […]

Many people assume that mitochondria (and free radicals) lie at the heart of aging or that they are “the cause” of aging. Despite having a central role in aging, the assumption that mitochondria cause aging is both simplistic and – not to put too fine a point on it – is totally at odds with […]

Why are we more likely to get cancer as we age? Not only does the incidence of cancer go up with age, but it goes up exponentially. Why? Moreover, the exponential rise is seen in most species, regardless of their lifespan. It’s not the years, it’s the aging process, regardless of time. Why? The key […]

As the human body is composed of cells, so are cells composed of molecules. It is true that the cell encompasses a plethora of organelles (membranes, mitochondria, nuclei, Golgi bodies, ribosomes, etc.), but each of these organelles is in turn composed of pools of various molecules. Just as cytoplasm is a “soup” of molecules, organelles […]

Effective maintenance is a product of the rate and the quality of the maintenance process. If we look at a car, for example, the long-term condition of the car depends on how often we institute maintenance (once a month or once every few years?) and the quality of the maintenance procedures (do you replace and […]

Everyone seems to “know” that telomeres have something to do with aging. The internet even has pop-up ads about foods that lengthen your telomeres, with the unstated assumption that will make your younger, or at least healthier. Inquiry shows, however, that not only do most people have no understanding of the role of telomeres in […]

How does aging work? So far, in the prologue (section 0) and the section 1 posts, we have discussed a perspective, what aging isn’t (and is), and what we need to explain in any accurate model of aging. In this post, I provide an overview of how the aging process occurs, from cell division to […]

What IS aging? An explanation of aging must account for all cells, all organisms, and – if we are candid – all of biology and isn’t merely entropy. Prior posts defined our boundaries: what we must include – and exclude. We know that we cannot simply point to entropy, wash our hands of any further […]

Our understanding is limited by our vision. If we look locally, our understanding is merely local; if we look globally, our understanding becomes more global; and if we look at our entire universe, then our understanding will be universal. When we attempt to understand our world, we often start with what we know best: our […]

It ain’t what you don’t know that gets you into trouble. It’s what you know for sure that just ain’t so. – Mark Twain Twain was right, particularly when it comes to the aging process: there is a lot we think we “know for sure that just ain’t so”. For example, most people (without even […]

Aging and Disease 0.1 – A Prologue Over the past 20 years, I have published numerous articles, chapters, and books explaining how aging and age-related disease work, as well as the potential for intervention in both aging and age-related disease. The first of these publications was Reversing Human Aging (1996), followed by my articles in […]

About a century ago, in a small American town, the first automobile chugged to a stop in front of the general store, where a local man stared at the apparition in disbelief, then asked “where’s your horse?” A long explanation followed, involving internal combustion, pistons, gasoline, and driveshafts. The local listened politely but with growing […]

Several of you have asked why I don’t update this blog more often. My priority is to take effective interventions for age-related diseases to FDA phase 1 human trials, rather than blogging about the process. Each week, Outlook reminds me to update the blog, but there are many tasks that need doing if we are […]

Why do Alzheimer’s interventions always fail? Whether you ask investors or pharmaceutical companies, it has become axiomatic that Alzheimer’s “has been a graveyard for many a company”, regardless of what they try. But in a fundamental way, all past and all current companies – whether big pharma or small biotech – try the same approach. […]