Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis and, ultimately, clinical cancer. Telomerase therapy is not only unlikely to result in […]
Those working with Alzheimer’s and other dementias have been frustrated by the implacability of these diseases. Regardless of limited symptomatic treatment, there are no proven disease-modifying interventions. Despite huge and growing costs of care, a pipeline of candidate drugs, >400 registered trials, tens of thousands of patients, billions of dollars in both US federal and […]
These are heady times for gene therapy, yet we have a long way to go before it achieves its promise. It is, to use an historical analogy, much like where aviation was in the first decade or two of the 20th century.Aviation has a fascinating and ironic history. It was in 1895, only 8 years […]